Complete List of Published Work in MyBibliography:
http://www.ncbi.nlm.nih.gov/sites/myncbi/alice.tomei.1/bibliography/48515548/public/?sort=date&direction=ascending
Manuscripts
Patents
Awarded
Book Chapters
http://www.ncbi.nlm.nih.gov/sites/myncbi/alice.tomei.1/bibliography/48515548/public/?sort=date&direction=ascending
Manuscripts
- De Toni T, Dal Buono T, Li CM, Gonzalez GC, Chuang ST, Buchwald P, Tomei AA, Velluto D. Drug Integrating Amphiphilic Nano-Assemblies: 2. Spatiotemporal Distribution within Inflammation Sites. Pharmaceutics (IF: 5.4). 2024 May 13;16(5):652. doi: 10.3390/pharmaceutics16050652. PMID: 38794314; PMCID: PMC11124943.
- Berishvili E, Peloso A, Tomei AA, Pepper AR. The Future of Beta Cells Replacement in the Era of Regenerative Medicine and Organ Bioengineering. Transpl Int. 2024 Mar 13;37:12885. doi: 10.3389/ti.2024.12885. PMID: 38544564; PMCID: PMC10966588.
- Asthana A, Chaimov D, Tamburrini R, Gazia C, Gallego A, Lozano T, Heo JH, Byers L, Tomei A, Fraker C, Walker S, Lee S, Opara E, Orlando G, Decellularized human pancreatic extracellular matrix-based physiomimetic microenvironment for human islet culture; Acta Biomater. (IF: 9.7) 2023 Nov;171:261-272. doi: 10.1016/j.actbio.2023.09.034. Epub 2023 Sep 22
- Xi Wang, Kai Wang, Ming Yu, Diana Velluto, Xuechong Hong, Bo Wang, Alan Chiu, Juan M. Melero-Martin, Alice A. Tomei, Minglin Ma, Engineered immunomodulatory accessory cells improve experimental allogeneic islet transplantation without immunosuppression; Science Advances (IF: 14.136) 2022 Jul 22;8(29):eabn0071.doi: 10.1126/sciadv.abn0071. Epub 2022 Jul 22
- Stock AA, Gonzalez GC, Pete SI, De Toni T, Berman DM, Rabassa A, Diaz W, Geary JC Jr, Willman M, Jackson JM, DeHaseth NH, Ziebarth NM, Hogan AR, Ricordi C, Kenyon NS, Tomei AA, Performance of islets of Langerhans conformally coated via an emulsion cross-linking method in diabetic rodents and nonhuman primates; Sci Adv. 2022 Jul; 8(26):eabm3145. doi: 10.1126/sciadv.abm3145. Epub 2022 Jun 29
- Zisi Tegou F, Velluto D, Stock AA, Fitzgerald SN, Stealey S, Zustiak SP, Bayer AL, Tomei AA, CCL21 and beta-cell antigen releasing hydrogels as tolerance-inducing therapy in Type I diabetes; J Control Release. 2022 Jun 16;348:499-517. doi: 10.1016/j.jconrel.2022.06.008. Online ahead of print
- De Toni T, Stock AA, Devaux F, Gonzalez GC, Nunez K, Rubanich JC, Safley SA, Weber CJ, Ziebarth NM, Buchwald P, Tomei AA, Parallel Evaluation of Polyethylene Glycol Conformal Coating and Alginate Encapsulation as Immunoisolation Strategies for Pancreatic Islet Transplantation; Front Bioeng Biotechnol. 2022 May 16;10:886483. doi: 10.3389/fbioe.2022.886483.eCollection 2022.
- Diana Velluto, Damir Bojadzic, Teresa De Toni, Peter Buchwald, Alice A. Tomei, Drug-integrating amphiphilic nanomaterial assemblies: 1. Spatiotemporal control of cyclosporine delivery and activity using nanomicelles and nanofibrils, Journal of Controlled Release 2020, ISSN 0168-3659, doi.org/10.1016/j.jconrel.2020.10.026
- Riccardo Tamburrini, Deborah Chaimov, Kevin Enck, Sean M. Muir, Amish Asthana,Justine Mariam Aziz, Sandrine Lablanche, Emily Tubbs, Tomei AA, Mark Van Dyke, Shay Soker, Emmanuel C Opara, Orlando G, A Detergent Free Protocol for the Decellularization of the Human Pancreas for the Production of a Soluble Extracellular Matrix (ECM), J Vis Exp. 2020 Sep 4;(163). doi: 10.3791/61663.PMID: 32955501 pubmed.ncbi.nlm.nih.gov/32955501/
- Susan A. Safley, Norma S. Kenyon, Dora M. Berman, Graham F. Barber, Hong Cui, Stephanie Duncanson, Teresa De Toni, Melissa Willman, Paul de Vos, Alice A Tomei, Athanassios Sambanis, Camillo Ricordi, Collin J. Weber, Microencapsulated Islet Allografts in Diabetic NOD Mice and Nonhuman Primates, European Review for Medical and Pharmacological Sciences (IF: 1.575) 2020, Aug,;24 (16): 8551-8565;pubmed.ncbi.nlm.nih.gov/32894560/
- Freddy Gonzalez Badillo, Flavia Zisi Tegou, Riccardo Masina, Shane Wright, Mackenzie Scully, Laura Harwell, Mike Lupp, Jorge Postigo-Fernandez, Remi J. Creusot, Tomei AA, Tissue-Engineered Stromal Reticula to Study Lymph Node Fibroblastic Reticular Cells in Type I Diabetes, Cellular and Molecular Bioengineering (CMBE) (IF: 2.5) 2020, special Young Innovator Award, doi.org/10.1007/s12195-020-00627-y
- Sibilla S, Manenti S, Cazzato T, Colombo F, Tomei AA, Redaelli A, Manzoli V, Consolo F, SPH multiphase modelling of an experimental microfluidic device for conformal coating of pancreatic islets, Medical Engineering and Physics (IF: 1.923), published online Dec31 (2020). www.sciencedirect.com/science/article/pii/S1350453320300060
- Stock AA, Manzoli V, De Toni T, Abreu MM, Poh YC, Ye L, Roose A, Pagliuca FW, Thanos C, and Tomei AA, Conformal Coating of Stem Cell-Derived Islets for Beta Cell Replacement in Type 1 Diabetes, Stem Cell Report, 2019 Dec 6; [Epub ahead of print] www.ncbi.nlm.nih.gov/pubmed/31839542
- Gonzalez-Badillo F, Zisi Tegou F, Abreu MM, Masina R, Sha D, Najjar M, Wright S, Bayer AL, Korpos E, Pugliese A, Molano RD, Tomei AA, "CCL21 Expression in Beta Cells Induces Fibroblastic Reticular Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice", published online in Diabetes, Aug 1 2019 www.ncbi.nlm.nih.gov/pubmed/31371518
- Tomei, A., "Engineering Confined and Pre-vascularized Sites for Transplantation". Transplantation; 2018 May 23 www.ncbi.nlm.nih.gov/pubmed/29794938
- Ciccocioppo R, Dos Santos CC, Baumgart DC, Cangemi GC, Cardinale V, Ciacci C, De Coppi P, Haldar D, Klersy C, Nostro MC, Ott M, Piemonti L, Tomei AA, Uygun B, Vetrano S, Orlando G., Proceedings of the signature series event of the international society for cellular therapy: "Advancements in cellular therapies and regenerative medicine in digestive diseases," London, United Kingdom, May 3, 2017, Cytotherapy. 2018 Feb 1 www.ncbi.nlm.nih.gov/pubmed/29398624
- Vita Manzoli, Chiara Villa, Allison L. Bayer, Laura Morales, R. Damaris Molano, Yvan Torrente, Camillo Ricordi, Jeffrey A. Hubbell, Alice A. Tomei, Immunoisolation of Murine Islet Allografts in Vascularized Sites Through Conformal Coating with Polyethylene Glycol. American Journal of Transplantation 2017 Oct 25 www.ncbi.nlm.nih.gov/pubmed/29068143
- Buchwald, P., Tamayo, A., Manzoli, V., Tomei, A., Stabler, C. (in press). Glucose-Stimulated Insulin Release: Parallel Perifusion Studies of Free and Hydrogel Encapsulated Human Pancreatic Islets. Biotechnology & Bioengineering 2017 Sept www.ncbi.nlm.nih.gov/pubmed/28865118
- Vita Manzoli, David C. Colter, Sridevi Dhanaraj, Alessia Fornoni, Camillo Ricordi, Antonello Pileggi and Alice A. Tomei, ‘Engineering Human Renal Epithelial Cells for Transplantation in Regenerative Medicine’, Med Eng Phys. 2017 Oct;48:3-13. www.ncbi.nlm.nih.gov/pubmed/28416198
- Chiara Villa, Vita Manzoli, Maria Abreu, Connor A. Verheyen, Michael Seskin, Mejdi Najjar, R. Damaris Molano, Yvan Torrente, Camillo Ricordi, Alice A. Tomei, ‘Composition and Transplant Site of Alginate-Polyethylene Glycol Microcapsules Affect the Outcome of the Encapsulated Islet Graft in Mice’, Transplantation 2016 Aug 12. [Epub ahead of print] www.ncbi.nlm.nih.gov/pubmed/27525644
- Tomei A.A., Villa C., Ricordi C, Development of an encapsulated stem cell-based therapy for diabetes’, Expert Opin Biol Ther. 2015 15(9):1321-36 - http://www.ncbi.nlm.nih.gov/pubmed/26156291
- Najjar M., Manzoli V., Villa C., Martino M.M., Molano R.D., Torrente Y., Pileggi A., Inverardi L., Ricordi C., Hubbell J.A., Tomei A.A., ‘Fibrin Gels Engineered with Pro-Angiogenic Growth Factors Promote Engraftment of Pancreatic Islets in Extrahepatic Sites in Mice’, Biotechnology and Bioengineering 2015 Mar 18 (Epub ahead of print). Highlighted - http://www.ncbi.nlm.nih.gov/pubmed/25786390
- Tomei A.A., Vita Manzoli, Christopher Fraker, Jaime A. Giraldo, Diana Velluto, Mejdi Najjar, Antonello Pileggi, Ruth D. Molano, Camillo Ricordi, Cherie L. Stabler, Jeffrey A. Hubbell, ‘Conformal Coating of Islets of Langerhans: Device Design and Materials Optimization’, PNAS 111 (29): 10514-9 (2014). Cover-art awarded - http://www.ncbi.nlm.nih.gov/pubmed/24982192
- Dane KY, Nembrini C, Tomei AA, Eby JK, O'Neil CP, Velluto D, Swartz MA, Inverardi L, Hubbell JA, “Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival”, J Control Release, 156(2):154-60 (2011) - http://www.ncbi.nlm.nih.gov/pubmed/21864593
- *Shields J.D., *Kourtis I., Tomei A.A., Roberts J., Swartz M.A., “Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21”, Science 328 (5979) 749-52 (2010) - http://www.ncbi.nlm.nih.gov/pubmed/20339029
- Tomei A.A., Siegert S., Britschgi M.R., Luther S.A., Swartz, M. A. “Fluid Flow Regulates Stromal Cell Organization and CCL21 Expression in a Tissue-engineered Lymph Node Microenvironment”, Journal of Immunology 183, 4273-83 (2009) - http://www.ncbi.nlm.nih.gov/pubmed/19734211
- Tomei A.A., Boschetti F., Gervaso F., Swartz, M. A. “3D Collagen Cultures Under Well-Defined Dynamic Strain: A Novel Strain Device with a Porous Elastomeric Support”, Biotechnology & Bioengineering 103, 217-25 (2009) - http://www.ncbi.nlm.nih.gov/pubmed/19148875
- Boschetti F., Tomei A.A., Turri S., Swartz M.A., Levi M., “Design, Fabrication and Characterization of a Composite Scaffold for Bone Tissue Engineering”, Journal of Artificial Organs 31, 697-707 (2008) - http://www.ncbi.nlm.nih.gov/pubmed/18825642
- Tomei A.A., Choe, M. M., Swartz, M. A. “Effects of Dynamic Compression on Lentiviral Transduction in an In Vitro Airway Wall Model”, AJP Lung 1, L79-86 (2008) - http://www.ncbi.nlm.nih.gov/pubmed/18024723
- Shields J.D., Fleury M.E., Yong C., Tomei A.A., Randolph G.J., Swartz M.A. “Autologous Chemotaxis as a Mechanism of Tumor Cell Homing to Lymphatics via Interstitial Flow and Autocrine CCR7 Signaling”, Cancer Cell 6, 526-38 (2007) - http://www.ncbi.nlm.nih.gov/pubmed/17560334
- *Choe, M. M., *Tomei A.A., Swartz, M. A. “Physiological 3D Tissue Model of the Airway Wall and Mucosa“, Nature Protocols 1, 357-362 (2006) - http://www.ncbi.nlm.nih.gov/pubmed/17406256
Patents
Awarded
- Title: Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation. Inventors: Tomei AA, Monteleone G, Buchwald P, Inverardi L, Pileggi A, Ricordi C. US Patent; Patent number: US10,443,056B (Oct 15, 2019). Publication number EP2839004 A1, Application number EP20130721452, PCT number PCT/US2013/037150, Publication date Feb 25, 2015, Filing date Apr 18, 2013, Priority date Apr 18, 2012. Licensed to: Nogra Pharma Ltd, University of Miami.
- Title: Ccr7 ligand delivery and co-delivery in immunotherapy. Inventors: Tomei AA., Shields, J., Kourtis, I., Swartz, M., Hubbell, J. Patent number: US 8,592,364B2 (Nov 26, 2013). Publication number: WO2011100460 A3; Application number: 13/025,009, Filing date: Feb 10, 2011; Priority date: Feb 11, 2010. Assigned to: Ecole Polytechnique Federale de Lausanne (EPFL).
- Title: Conformal Coating of Cells and Cell Clusters. Inventors: Tomei AA, Hubbell JA, US Patent App. 18/113,449. Patent Application US20140147483A1, Publication number US2017/0216489A1 (Aug. 3, 2017). International publication number: WO 2012/149496 AlLicensed to: Converge Biotech (Nov. 1, 2012). 2020-05-26 Application granted.
Book Chapters
- Teles L, Li CM, Wilkes Z, Stock AA, Tomei AA, Chapter: Islet Immunonegineering; for Stem Cell Therapy for Diabetes, edited by Lorenzo Piemonti, Jon Odorico, Timothy J . Kieffer, Valeria Sordi and Eelco de Koning , Springer Cham; Published: 19 February 2024; https://doi.org/10.1007/978-3-031-41943-0
- Stock AA, Tomei AA, Conformal Coating, In: Orlando G, Piemonti L, Ricordi C, Stratta RJ, and Gruessner RWG, (eds). Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2. San Diego: Elsevier Inc./Academic Press, November 1 (2019)