Islet Immunoengineering Lab
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Manuscripts​
  1. Zisi Tegou F, Velluto D, Stock AA, Fitzgerald SN, Stealey S, Zustiak SP, Bayer AL, Tomei AA, CCL21 and beta-cell antigen releasing hydrogels as tolerance-inducing therapy in Type I diabetes; J Control Release. 2022 Jun 16;348:499-517. doi: 10.1016/j.jconrel.2022.06.008. Online ahead of print
  2. De Toni T, Stock AA, Devaux F, Gonzalez GC, Nunez K, Rubanich JC, Safley SA, Weber CJ, Ziebarth NM, Buchwald P, Tomei AA, Parallel Evaluation of Polyethylene Glycol Conformal Coating and Alginate Encapsulation as Immunoisolation Strategies for Pancreatic Islet Transplantation; Front Bioeng Biotechnol. 2022 May 16;10:886483. doi: 10.3389/fbioe.2022.886483.eCollection 2022.
  3. Diana Velluto, Damir Bojadzic, Teresa De Toni, Peter Buchwald, Alice A. Tomei, Drug-integrating amphiphilic nanomaterial assemblies: 1. Spatiotemporal control of cyclosporine delivery and activity using nanomicelles and nanofibrils, Journal of Controlled Release 2020, ISSN 0168-3659, doi.org/10.1016/j.jconrel.2020.10.026
  4. Riccardo Tamburrini, Deborah Chaimov, Kevin Enck, Sean M. Muir, Amish Asthana,Justine Mariam Aziz, Sandrine Lablanche,  Emily Tubbs, Tomei AA, Mark Van Dyke, Shay Soker, Emmanuel C Opara, Orlando G, A Detergent Free Protocol for the Decellularization of the Human Pancreas for the Production of a Soluble Extracellular Matrix (ECM), J Vis Exp. 2020 Sep 4;(163). doi: 10.3791/61663.PMID: 32955501 pubmed.ncbi.nlm.nih.gov/32955501/
  5. Susan A. Safley, Norma S. Kenyon, Dora M. Berman, Graham F. Barber, Hong Cui, Stephanie Duncanson, Teresa De Toni,  Melissa Willman,  Paul de Vos, Alice A Tomei, Athanassios Sambanis, Camillo Ricordi, Collin J. Weber, Microencapsulated Islet Allografts in Diabetic NOD Mice and Nonhuman Primates, European Review for Medical and Pharmacological Sciences (IF: 1.575) 2020, Aug,;24 (16): 8551-8565;pubmed.ncbi.nlm.nih.gov/32894560/
  6. Freddy Gonzalez Badillo, Flavia Zisi Tegou, Riccardo Masina, Shane Wright, Mackenzie Scully, Laura Harwell, Mike Lupp, Jorge Postigo-Fernandez, Remi J. Creusot, Tomei AA, Tissue-Engineered Stromal Reticula to Study Lymph Node Fibroblastic Reticular Cells in Type I Diabetes, Cellular and Molecular Bioengineering (CMBE) (IF: 2.5) 2020, special Young Innovator Award, doi.org/10.1007/s12195-020-00627-y
  7. Sibilla S, Manenti S, Cazzato T, Colombo F, Tomei AA, Redaelli A, Manzoli V, Consolo F, SPH multiphase modelling of an experimental microfluidic device for conformal coating of pancreatic islets, Medical Engineering and Physics (IF: 1.923), published online Dec31 (2020). www.sciencedirect.com/science/article/pii/S1350453320300060
  8. Stock AA, Manzoli V, De Toni T, Abreu MM, Poh YC, Ye L, Roose A, Pagliuca FW, Thanos C, and Tomei AA, Conformal Coating of Stem Cell-Derived Islets for Beta Cell Replacement in Type 1 Diabetes, Stem Cell Report, 2019 Dec 6;  [Epub ahead of print] www.ncbi.nlm.nih.gov/pubmed/31839542
  9. Gonzalez-Badillo F, Zisi Tegou F, Abreu MM, Masina R, Sha D, Najjar M, Wright S, Bayer AL, Korpos E, Pugliese A, Molano RD, Tomei AA, "CCL21 Expression in Beta Cells Induces Fibroblastic Reticular Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice", published online in Diabetes, Aug 1 2019 www.ncbi.nlm.nih.gov/pubmed/31371518
  10. Tomei, A., "Engineering Confined and Pre-vascularized Sites for Transplantation". Transplantation; 2018 May 23 www.ncbi.nlm.nih.gov/pubmed/29794938
  11. Ciccocioppo R, Dos Santos CC, Baumgart DC, Cangemi GC, Cardinale V, Ciacci C, De Coppi P, Haldar D, Klersy C, Nostro MC, Ott M, Piemonti L, Tomei AA, Uygun B, Vetrano S, Orlando G., Proceedings of the signature series event of the international society for cellular therapy: "Advancements in cellular therapies and regenerative medicine in digestive diseases," London, United Kingdom, May 3, 2017, Cytotherapy. 2018 Feb 1 www.ncbi.nlm.nih.gov/pubmed/29398624
  12. Vita Manzoli, Chiara Villa, Allison L. Bayer, Laura Morales, R. Damaris Molano, Yvan Torrente, Camillo Ricordi, Jeffrey A. Hubbell, Alice A. Tomei, Immunoisolation of Murine Islet Allografts in Vascularized Sites Through Conformal Coating with Polyethylene Glycol. American Journal of Transplantation 2017 Oct 25 www.ncbi.nlm.nih.gov/pubmed/29068143
  13. Buchwald, P., Tamayo, A., Manzoli, V., Tomei, A., Stabler, C. (in press). Glucose-Stimulated Insulin Release: Parallel Perifusion Studies of Free and Hydrogel Encapsulated Human Pancreatic Islets. Biotechnology & Bioengineering 2017 Sept www.ncbi.nlm.nih.gov/pubmed/28865118
  14. Vita Manzoli, David C. Colter, Sridevi Dhanaraj, Alessia Fornoni, Camillo Ricordi, Antonello Pileggi and Alice A. Tomei, ‘Engineering Human Renal Epithelial Cells for Transplantation in Regenerative Medicine’, Med Eng Phys. 2017 Oct;48:3-13. www.ncbi.nlm.nih.gov/pubmed/28416198
  15. Chiara Villa, Vita Manzoli, Maria Abreu, Connor A. Verheyen, Michael Seskin, Mejdi Najjar, R. Damaris Molano, Yvan Torrente, Camillo Ricordi, Alice A. Tomei, ‘Composition and Transplant Site of Alginate-Polyethylene Glycol Microcapsules Affect the Outcome of the Encapsulated Islet Graft in Mice’, Transplantation 2016 Aug 12. [Epub ahead of print] www.ncbi.nlm.nih.gov/pubmed/27525644
  16. Tomei A.A., Villa C., Ricordi C, Development of an encapsulated stem cell-based therapy for diabetes’, Expert Opin Biol Ther. 2015 15(9):1321-36 - http://www.ncbi.nlm.nih.gov/pubmed/26156291
  17. Najjar M., Manzoli V., Villa C., Martino M.M., Molano R.D., Torrente Y., Pileggi A., Inverardi L., Ricordi C., Hubbell J.A., Tomei A.A., ‘Fibrin Gels Engineered with Pro-Angiogenic Growth Factors Promote Engraftment of Pancreatic Islets in Extrahepatic Sites in Mice’, Biotechnology and Bioengineering 2015 Mar 18 (Epub ahead of print). Highlighted - http://www.ncbi.nlm.nih.gov/pubmed/25786390
  18. Tomei A.A., Vita Manzoli, Christopher Fraker, Jaime A. Giraldo, Diana Velluto, Mejdi Najjar, Antonello Pileggi, Ruth D. Molano, Camillo Ricordi, Cherie L. Stabler, Jeffrey A. Hubbell, ‘Conformal Coating of Islets of Langerhans: Device Design and Materials Optimization’, PNAS 111 (29): 10514-9 (2014). Cover-art awarded - http://www.ncbi.nlm.nih.gov/pubmed/24982192
  19. Dane KY, Nembrini C, Tomei AA, Eby JK, O'Neil CP, Velluto D, Swartz MA, Inverardi L, Hubbell JA, “Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival”, J Control Release, 156(2):154-60 (2011) - http://www.ncbi.nlm.nih.gov/pubmed/21864593
  20. *Shields J.D., *Kourtis I., Tomei A.A., Roberts J., Swartz M.A., “Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21”, Science 328 (5979) 749-52 (2010) - http://www.ncbi.nlm.nih.gov/pubmed/20339029
  21. Tomei A.A., Siegert S., Britschgi M.R., Luther S.A., Swartz, M. A. “Fluid Flow Regulates Stromal Cell Organization and CCL21 Expression in a Tissue-engineered Lymph Node Microenvironment”, Journal of Immunology 183, 4273-83 (2009) - http://www.ncbi.nlm.nih.gov/pubmed/19734211
  22. Tomei A.A., Boschetti F., Gervaso F., Swartz, M. A. “3D Collagen Cultures Under Well-Defined Dynamic Strain: A Novel Strain Device with a Porous Elastomeric Support”, Biotechnology & Bioengineering 103, 217-25 (2009) - http://www.ncbi.nlm.nih.gov/pubmed/19148875
  23. Boschetti F., Tomei A.A., Turri S., Swartz M.A., Levi M., “Design, Fabrication and Characterization of a Composite Scaffold for Bone Tissue Engineering”, Journal of Artificial Organs 31, 697-707 (2008) - http://www.ncbi.nlm.nih.gov/pubmed/18825642
  24. Tomei A.A., Choe, M. M., Swartz, M. A. “Effects of Dynamic Compression on Lentiviral Transduction in an In Vitro Airway Wall Model”, AJP Lung 1, L79-86 (2008) - http://www.ncbi.nlm.nih.gov/pubmed/18024723
  25. Shields J.D., Fleury M.E., Yong C., Tomei A.A., Randolph G.J., Swartz M.A. “Autologous Chemotaxis as a Mechanism of Tumor Cell Homing to Lymphatics via Interstitial Flow and Autocrine CCR7 Signaling”, Cancer Cell 6, 526-38 (2007) - http://www.ncbi.nlm.nih.gov/pubmed/17560334
  26. *Choe, M. M., *Tomei A.A., Swartz, M. A. “Physiological 3D Tissue Model of the Airway Wall and Mucosa“, Nature Protocols 1, 357-362 (2006) - http://www.ncbi.nlm.nih.gov/pubmed/17406256


Patents
  1. Alice A. Tomei, Jacqueline Shields, Iraklis Kourtis, Jeffrey Hubbell, Melody Swartz, “CCL-21 and CCL-19 Delivery and Co-delivery in Immunotherapy”. Application number: 13/025,009
Publication number: US 2011/0206759 A1
Filing date: Feb 10, 2011
  2. Alice A. Tomei and Jeffrey A. Hubbell, “Conformal Coating of Cells and Cell Clusters”. Application file reference 104957013WO1 filed with the United States Patent and Trademark Office on October 29, 2013

 


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